Release time :2024-10-29
Source:support@yingchitech.com
Scan:69
The International Association for the Study of Pain has designated the third Monday of October each year as "World Pain Day." Neuropathic pain (NP) refers to pain caused by damage or disease affecting the somatosensory system. It is characterized by injury to the central or peripheral nervous system and is one of the most difficult types of pain to treat in clinical settings, with an annual incidence rate of 0.82%.
Functional magnetic resonance imaging (fMRI) has enabled researchers to discover the potential pain-relieving effects of TMS. TMS can alleviate pain through multiple mechanisms, including altering cortical excitability, improving cerebral blood flow, activating or inhibiting pain perception areas, changing neural plasticity, influencing the hypothalamic-pituitary-adrenal (HPA) axis, and regulating neurotransmitters and inflammatory factors.
In areas such as chronic pain and neuropathic pain, TMS technology has already demonstrated significant therapeutic effects. In the 2019 "Evidence-Based Guidelines for TMS Therapy" published by the International Federation of Clinical Neurophysiology (IFCN), high-frequency rTMS stimulation of the contralateral M1 region is rated as an A-level recommendation for treating neuropathic pain. This shows that TMS can be confidently used in clinical practice to improve patients' pain symptoms.
We have reviewed the literature to gather treatment protocols for various pain-related indications using TMS and have provided a summary of the underlying mechanisms.
Target | Intensity | Frequency | Number of Trains | ITI | Number of Sessions |
Occipital Cortex | 100%RMT | iTBS(50Hz/5Hz) | 20 | 10s | 5 sessions per week for two weeks |
Target | Intensity | Frequency | Train Duration | ITI | Total Pulses |
Healthy Side M1 | 80%RMT | 10Hz | 0.5S | 3s | 1500 |
Target | Intensity | Frequency | Train Duration | ITI | Total Pulses |
M1 on the Painful side of the body | 110%RMT | 10Hz | 5s | 25s | 1500 |
Target | Frequency | Total Pulses | Duration |
Bilateral M1 | 1Hz | 1000 | 15min per side, 1 session per day |
Target | Intensity | Frequency | Train Duration | ITI | Total Pulses |
L-DLPFC | 120%RMT | 10Hz | 4s | 21s | 3000 |
Target | Intensity | Frequency | Train Duration | ITI | Total Pulses |
Healthy Side M1 | 80%RMT | 10Hz | 0.5s | 3s | 1500 |
Target | Frequency | Train Duration | ITI | Total Pulses |
median nerve | 10Hz | 1s | 5s | 1000 |
Target | Frequency | Train Duration | ITI | Total Pulses |
Lumbar | 10Hz | 0.5s | 5s | 1000 |
1. This content is organized by the Clinical Support Department of Shenzhen Yingchi Technology Co.,Ltd. Criticisms and corrections are welcome. For reprint, please indicate the source.
2. Reference:
[1] Dana E, Tran C, Osokin E, Westwood D, Moayedi M, Sabhaya P, Khan JS. Peripheral magnetic stimulation for chronic peripheral neuropathic pain: A systematic review and meta-analysis. Pain Pract. 2024 Apr;24(4):647-658. doi: 10.1111/papr.13332. Epub 2023 Dec 16. PMID: 38102884.
[2] Zhou J, Wang Y, Luo X, Fitzgerald PB, Cash RFH, Fitzgibbon BM, Che X. Revisiting the effects of rTMS over the dorsolateral prefrontal cortex on pain: An updated systematic review and meta-analysis. Brain Stimul. 2024 Jul-Aug;17(4):928-937. doi: 10.1016/j.brs.2024.07.011. Epub 2024 Jul 30. PMID: 39089648.
[3] Cioni B, Meglio M. Motor cortex stimulation for chronic non-malignant pain: current state and future prospects[J]. Acta Neurochir Suppl, 2007, 97(Pt 2):45-49
[4] Pridmore S, Oberoi G, Marcolin M, et al . Transcranial magnetic stimulation and chronic pain: current status[J]. Australas Psychiatry, 2005, 13(3):258-265.
[5] Yohei T, Shingo O, Takashi O, et al . Effects of 1-Hz repetitive transcranial magnetic stimulation on acute pain induced by capsaicin[J]. Pain, 2004, 107(1-2):107-115.